TABLE 2.

Pair-wise correlations among Alzheimer’s disease (AD)-related molecules and tight junction proteins in the temporal cortex of AD cases

				Spearman’s r (P-value)
	apoETX	apoEFA		Aβ40 TX	Aβ40FA	Aβ42 TBS	Aβ42 TX	Aβ42FA	T-tau TBS	T-tau TX	T-tau FA	p-tau TBS	p-tau TX	p-tau FA	CLDN5 TX	OCLN TX
ApoE TBS	0.45 (<0.001)	0.01 (0.85)	−0.07 (0.11)	−0.06 (0.19)	−0.15 (0.002)	0.14 (0.003)	0.01 (0.76)	−0.09 (0.046)	0.26 (<0.001)	0.23 (<0.001)	0.18 (<0.001)	0.26 (<0.001)	−0.04 (0.38)	−0.01 (0.83)	−0.29 (<0.001)	−0.26 (<0.001)
TX	1.00	0.27 (<0.001)	0.12 (0.011)	0.33 (<.0001)	0.03 (0.58)	−0.12 (0.008)	0.01 (0.77)	−0.07 (0.15)	0.34 (<0.001)	0.01 (0.87)	−0.15 (0.001)	0.04 (0.44)	−0.13 (0.004)	−0.07 (0.15)	−0.18 (<0.001)	−0.31 (<0.001)
FA	-	1.00	0.31 (<0.001)	0.37 (<0.001)	0.48 (<0.001)	0.07 (0.11)	0.08 (0.068)	0.08 (0.095)	−0.10 (0.027)	−0.18 (<0.001)	0.24 (<0.001)	0.01 (0.72)	0.29 (<0.001)	0.45 (<0.001)	−0.17 (<0.001)	−0.06 (0.21)
Aβ40 TBS	-	-	1.00	0.52 (<0.001)	0.63 (<0.001)	0.29 (<0.001)	0.22 (<0.001)	0.15 (0.001)	0.06 (0.17)	0.08 (0.100)	0.07 (0.13)	−0.06 (0.16)	0.00 (0.99)	0.09 (0.059)	−0.04 (0.35)	0.01 (0.83)
TX	-	-	-	1.00	0.55 (<0.001)	0.13 (0.004)	0.25 (<0.001)	0.07 (0.15)	0.03 (0.51)	−0.04 (0.44)	−0.08 (0.069)	−0.04 (0.38)	0.04 (0.40)	0.05 (0.30)	−0.04 (0.41)	−0.10 (0.030)
FA	-	-	-	-	1.00	0.21 (<0.001)	0.19 (<0.001)	0.23 (<0.001)	−0.12 (0.009)	−0.06 (0.22)	0.12 (0.013)	−0.07 (0.13)	0.21 (<0.001)	0.25 (<0.001)	0.02 (0.72)	0.09 (0.042)
Aβ42 TBS	-	-	-	-	-	1.00	0.66 (<0.001)	0.41 (<0.001)	0.23 (<0.001)	0.44 (<0.001)	0.39 (<0.001)	0.34 (<0.001)	0.11 (0.022)	0.19 (<0.001)	−0.17 (<0.001)	0.18 (<0.001)
TX	-	-	-	-	-	-	1.00	0.53 (<0.001)	0.20 (<0.001)	0.39 (<0.001)	0.29 (<0.001)	0.27 (<0.001)	0.22 (<0.001)	0.17 (<0.001)	−0.05 (0.31)	0.26 (<0.001)
FA	-	-	-	-	-	-	-	1.00	0.05 (0.25)	0.18 (<0.001)	0.22 (<0.001)	0.08 (0.10)	0.21 (<0.001)	0.17 (<0.001)	0.04 (0.40)	0.32 (<0.001)
T-tau TBS	-	-	-	-	-	-	-	-	1.00	0.60 (<0.001)	0.07 (0.14)	0.09 (0.045)	−0.21 (<0.001)	−0.38 (<0.001)	−0.26 (<0.001)	−0.15 (0.001)
TX	-	-	-	-	-	-	-	-	-	1.00	0.29 (<0.001)	0.16 (<0.001)	−0.54 (<0.001)	−0.29 (<0.001)	−0.18 (<0.001)	0.17 (<0.001)
FA	-	-	-	-	-	-	-	-	-	-	1.00	0.14 (0.002)	0.14 (0.002)	0.39 (<0.001)	−0.13 (0.005)	0.18 (<0.001)
p-Tau TBS	-	-	-	-	-	-	-	-	-	-	-	1.00	0.24 (<0.001)	0.03 (0.45)	−0.03 (0.49)	0.15 (<0.001)
TX	-	-	-	-	-	-	-	-	-	-	-	-	1.00	0.61 (<0.001)	0.07 (0.15)	0.24 (<0.001)
FA	-	-	-	-	-	-	-	-	-	-	-	-	-	1.00	−0.15 (0.002)	0.06 (0.19)
CLDN5 TX															1.00	0.48 (<0.001)
OCLN TX	-	-	-	-	-	-	-	-	-	-	-	-	-		-	1.00

P-values <.05 were considered statistically significant in this exploratory correlation analysis; statistically significant correlations are shown in bold.

Abbreviation: APOE, apolipoprotein E; CAA, cerebral amyloid angiopathy; FA, formic acid; TBS, Tris-buffered saline; TX, 1% Triton X-100