Table 1.

The role of nitric oxide in peptic ulcer

Disease	Injury type	Animal	Result
Gastric ulcer	Hypertonic NaCl solution	Rat	NO is involved in the mechanism of the gastric alkaline response which occurs in the stomach after exposing to hypertonic NaCl.
Gastric ulcer	Non-steroidal anti-inflammatory drugs	Rat	NO could reduce the severity of gastric and intestinal damage.
Gastric ulcer	Ethanol	Rat	NO may have therapeutic effect on gastric ulcer mucosal lesions. This effect may be realized by the anti-inflammatory, angiogenesis and antiapoptosis effects of NO.
Gastric lesion	HCl	Rat	NO significantly inhibits the HCl-induced gastric lesion formation in rats.
Duodenal ulcer	Helicobacter pylori infection	Mouse	NO binds to superoxide to produce peroxynitrite that is involved in epithelial damage associated with H. pylori infection.

Note: NO: Nitric oxide.