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. 2021 Apr 23;13:631172. doi: 10.3389/fnagi.2021.631172

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Copyright © 2021 Michels, Riese, Meyer, Kälin, Leh, Unschuld, Luechinger, Hock, O'Gorman, Kollias and Gietl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustration of the whole-brain mALFF findings. (A) Higher BOLD signal amplitudes were seen in patients with MCI compared to controls (indicated in green) in the left supramarginal gyrus (SMG), middle temporal gyrus (MTG), subgenual anterior cingulate cortex (sACC), posterior cingulate cortex (PCC), parahippocampal gyrus (PHG), and other regions (see Results section). HCS showed higher absolute BOLD signal amplitudes in the MPFC and IFG and other regions (see Results section). (B) PiB+ individuals demonstrate higher BOLD signals in the hippocampus (HC), central operculum (CO) and PCC. The PiB- group revealed stronger BOLD signal in the inferior temporal gyrus, cerebellum exterior (Cex), and inferior occipital gyrus (IOG). All results are shown at p < 0.05 corrected (t > 2.7).