Table 1.
Demographic and clinical data for HCS and MCI.
| Group | HCS (n = 21) | MCI (n = 14) | p-value |
|---|---|---|---|
| Global-β-amyloid (Mean/SD) | 1.23 (0.2) | 1.45 (0.4) | 0.05 |
| Amyloid-status (PiB+/PiB-) | 6/15 | 6/8 | >0.05 |
| ApoE ε4 carrier | 5 | 4 | >0.05 |
| Gender (F/M) | 7/14 | 5/9 | >0.05 |
| Age in years (Mean/SD) | 71.8 (4.2) | 75.6 (8.9) | >0.05 |
| Level of education (years) | 14.6 (2.9) | 14.2 (3.8) | >0.05 |
| Cognitive variables | |||
| MMSE, /30 | 29.6 (0.7) | 28.5 (1.6) | <0.001 |
| DS (forward) | 0.07 (0.8) | −0.4 (0.9) | 0.14 |
| DS (backward) | 0.61 (1.1) | −0.1 (1.1) | 0.07 |
| Trail making (B/A) | −0.12 (1.1) | −0.5 (1.0) | 0.71 |
| Letter fluency | 0.17 (1.3) | −0.5 (0.8) | 0.12 |
| Category fluency | 0.51 (1.3) | −0.3 (0.7) | 0.04 |
| Number of figures | 0.3 (1.0) | −0.3 (0.8) | 0.09 |
| Stroop Interference | 0.52 (0.5) | −0.2 (1.1) | 0.02 |
| Boston naming | 0.32 (0.7) | −0.4 (1.0) | 0.02 |
| VLMT learning | 0.62 (0.6) | −0.9 (0.7) | <0.001 |
| VLMT recognition | 0.50 (0.7) | −0.7(0.9) | <0.001 |
| VLMT delayed recall | 0.66 (0.5) | −0.9 (0.7) | <0.001 |
| CERAD recall | 0.55 (0.6) | −0.8 (0.9) | <0.001 |
| CERAD word learning | 0.53 (0.8) | −0.7 (0.8) | <0.001 |
HCS and MCI did not differ in gender distribution (F = female, M = male), age, APOE ε4 (all p > 0.05) but in Aβ deposition (p = 0.05 with MCI > HCS). Cognitive variables are z-transformed raw scores (means and standard deviations) except for MMSE. MCI showed significantly lower test scores for MMSE as well as for category fluency, Stroop interference, Boston naming tests, and – most pronounced – for memory related tests (VLMT and CERAD). MMSE, Mini mental status examination.
Bold values indicate significant group differences.