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The conceptual framework is adapted from the diathesis-stress model for depression (Monroe and Simons, 1991). The aim of the present study was to investigate the association between acute stress and IMDs (A). We postulated that acute stress would interact with vulnerability factors [B; genetic (yellow block), acquired (pink block), or both (blue block)] to increase the risk for IMDs. SLC6A4, serotonin transporter gene; TPH2, tryptophan hydroxylase 2 gene.
