Table 2.

Distribution of genotypes and Hardy-Weinberg equilibrium analysis between cases and controls for SLC6A4 [5-HTTLPR, rs25531, 5-HTTLPR-rs25531, and STin2 VNTR] and TPH2 [rs1843809, rs1386494, rs34517220, and rs4570625] polymorphisms.

Genotype	Cases (n = 368) n (%)	Controls (n = 368) n (%)	p*	HWE Cases	HWE Controls
5-HTTLPR (n = 698)			0.286	0.323	0.1916
LL	223 (62.3)	231 (67.9)
LS	115 (32.1)	94 (27.7)
SS	20 (5.6)	15 (4.4)
rs25531 (n = 685)			0.988	0.795	0.641
AA	227 (65.4)	221 (65.4)
AG	108 (31.1)	106 (31.4)
GG	12 (3.5)	11 (3.2)
5-HTTLPR-rs25531 haplotype (n = 685)			0.688	N/A	N/A
L-A-L-A	130 (37.4)	136 (40.2)
L-A-L-G	76 (21.9)	82 (24.3)
L-A-S-A	79 (22.8)	71 (21.0)
L-A-S-G	2 (0.6)	Absent
L-G-L-G	12 (3.5)	11 (3.3)
S-A-S-A	18 (5.2)	15 (4.4)
S-A-L-G	30 (8.6)	23 (6.8)
STin2 VNTR (n = 687)			0.203	0.090	0.440
10/10	26 (7.5)	28 (8.8)
10/12	126 (36.3)	112 (35.3)
12/12	189 (54.5)	177 (55.9)
9/9	5 (1.4)	Absent
9/12	1 (0.3)	Absent
rs1843809 (n = 686)			0.003	0.009	0.537
TT	105 (30.1)	113 (33.5)
TG	150 (43.0)	169 (50.2)
GG	94 (26.9)	55 (16.3)
rs1386494 (n = 685)			0.06	0.956	0.007
GG	210 (59.7)	202 (60.7)
GA	124 (35.2)	125 (37.5)
AA	18 (5.1)	6 (1.8)
rs34517220 (n = 685)			0.945	0.557	0.913
AA	90 (25.6)	84 (25.1)
AG	170 (48.4)	166 (49.7)
GG	91 (25.9)	84 (25.2)
rs4570625 (n = 683)			0.574	0.787	0.229
GG	88 (25.2)	90 (26.9)
GT	177 (50.7)	156 (46.7)
TT	84 (24.1)	88 (26.4)

5-HTTLPR, serotonin transporter linked polymorphic region; STin2 VNTR, serotonin transporter intron 2 variable number of tandem repeats; HWE, Hardy-Weinberg equilibrium; N/A, not applicable.

^*Value of p for association of each investigated polymorphism with IMDs.