Table 5.

Logistic regression analyses for the interaction of acute stress with 5-HTTLPR-rs25531 and chronic stress, respectively, on IMDs.

Model	Variable	Odds ratio	p > |Z|	95% CI	p
Excluding any polymorphism or chronic stress	Mild acute stress	Reference			0.046a
	Moderate acute stress	1.22	0.282	0.848–1.761
	Severe acute stress	1.92	0.001	1.327–2.785
Including 5-HTTLPR-rs25531	Acute stress*5-HTTLPR-rs25531
	Mild AS*L-A-S-G	1			0.049b
	Moderate AS*L-A-L-G	2.52	0.022	1.142–5.540
	Moderate AS*L-A-S-A	1.60	0.235	0.736–3.497
	Moderate AS*L-A-S-G	0.63	0.124	0.351–1.135
	Moderate AS*L-G-L-G	0.83	0.870	0.092–7.535
	Moderate AS*S-A-L-G	1.48	0.563	0.395–5.500
	Moderate AS*S-A-S-A	14.83	0.030	1.294–170.010
	Severe AS*L-A-L-G	3.72	0.002	1.630–8.474
	Severe AS*L-A-S-A	2.82	0.013	1.248–6.350
	Severe AS*L-A-S-G	1.16	0.629	0.641–2.091
	Severe AS*L-G-L-G	0.85	0.872	0.121–6.010
	Severe AS*S-A-L-G	1.58	0.493	0.426–5.881
	Severe AS*S-A-S-A	11.95	0.011	1.755–81.331
Including chronic stress	Acute stress*Chronic stress
	Moderate AS*moderate CS	1.04	0.896	0.607–1.768	0.033c
	Moderate AS*severe CS	1.80	0.035	1.041–3.106
	Severe AS*moderate CS	0.95	0.904	0.406–2.217
	Severe AS*severe CS	4.28	0.001	1.832–10.012

AS, acute stress; CS, chronic stress; Acute stress*5-HTTLPR-rs25531, interaction between acute stress and 5-HTTLPR-rs25531 genotypes on internalizing mental disorder (IMDs).

^aValue of p for association between acute stress and IMDs (the model without chronic stress/SLC6A4).

^bValue of p for the likelihood-ratio test of interaction between acute stress and 5-HTTLPR-rs25531 on IMDs.

^cValue of p for the likelihood-ratio test of interaction between acute stress and chronic stress on IMDs.