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Illustration of the potential mechanism concluded by this study. The inhibitory effect of CS-6 on functional OC formation may be in part ascribed to the inhibition of NF-kB and ERK/MAPK signaling via lessening the binding of TRAF6 to RANK and consequently the activation of c-Fos and NFATc1. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
