Table 2.
Clinical features of PCOS and associations with vaginal microbiota.
| Clinical features | Frequency | % | Shannon index* | R2 (P value)& | |
|---|---|---|---|---|---|
| Overweight/Obesity | No | 54 | 60.7 | 1.21 (1.25) | 0.012 (0.094) |
| Yes | 35 | 39.3 | 1.18 (1.52) | ||
| P=0.675 | |||||
| WHR | <0.8 | 34 | 38.2 | 1.15 (1.21) | 0.019 (0.211) |
| ≥0.8 | 54 | 60.7 | 1.19 (1.31) | ||
| Missing | 1 | P=0.644 | |||
| Body hair | Normal | 43 | 48.3 | 1.22 (1.08) | 0.011 (0.139) |
| Hirsutism | 46 | 51.7 | 1.19 (1.54) | ||
| P=0.736 | |||||
| Acne | No | 8 | 9.0 | 0.83 (1.70) | 0.010 (0.199) |
| Yes | 81 | 91.0 | 1.22 (1.27) | ||
| P=0.315 | |||||
| Acanthosis nigricans | No | 60 | 67.4 | 1.15 (1.43) | 0.070 (0.001) |
| Yes | 29 | 32.6 | 1.22 (1.26) | ||
| P=0.834 | |||||
| Intermenstrual bleeding | No | 64 | 71.9 | 1.06 (1.10) | 0.024 (0.010) |
| Yes | 25 | 28.1 | 1.71 (1.36) | ||
| P=0.093 | |||||
| Pregnancy history | No | 57 | 64.0 | 1.20 (1.27) | 0.025 (0.006) |
| Yes | 32 | 36.0 | 1.23 (1.50) | ||
| P=0.578 |
*Data are presented as median (interquartile range). The Kruskal-Wallis method was used to examine differences between groups.
&PERMANOVA was performed based on binary Jaccard distance among different groups. R2 signifies the proportion of variation in distances that can be explained by the groups tested. P values were adjusted for sequencing batch.
WHR, Waist-hip ratio. Bold value means it is statistically significant (P < 0.05).