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. 2021 Apr 23;12:662725. doi: 10.3389/fendo.2021.662725

Table 2.

Clinical features of PCOS and associations with vaginal microbiota.

Clinical features Frequency % Shannon index* R2 (P value)&
Overweight/Obesity No 54 60.7 1.21 (1.25) 0.012 (0.094)
Yes 35 39.3 1.18 (1.52)
P=0.675
WHR <0.8 34 38.2 1.15 (1.21) 0.019 (0.211)
≥0.8 54 60.7 1.19 (1.31)
Missing 1 P=0.644
Body hair Normal 43 48.3 1.22 (1.08) 0.011 (0.139)
Hirsutism 46 51.7 1.19 (1.54)
P=0.736
Acne No 8 9.0 0.83 (1.70) 0.010 (0.199)
Yes 81 91.0 1.22 (1.27)
P=0.315
Acanthosis nigricans No 60 67.4 1.15 (1.43) 0.070 (0.001)
Yes 29 32.6 1.22 (1.26)
P=0.834
Intermenstrual bleeding No 64 71.9 1.06 (1.10) 0.024 (0.010)
Yes 25 28.1 1.71 (1.36)
P=0.093
Pregnancy history No 57 64.0 1.20 (1.27) 0.025 (0.006)
Yes 32 36.0 1.23 (1.50)
P=0.578

*Data are presented as median (interquartile range). The Kruskal-Wallis method was used to examine differences between groups.

&PERMANOVA was performed based on binary Jaccard distance among different groups. R2 signifies the proportion of variation in distances that can be explained by the groups tested. P values were adjusted for sequencing batch.

WHR, Waist-hip ratio. Bold value means it is statistically significant (P < 0.05).