Table 2.
Parameters of ovarian stimulation and embryo transfer.
| Characteristics | Group A | Group B | P |
|---|---|---|---|
| n=666 | n=814 | ||
| Duration of stimulation (days) | 9.86 ± 1.46 | 9.77 ± 1.40 | 0.223 |
| Total gonadotrophin dose (IU) |
2297.54 ± 788.52 | 2327.99 ± 804.57 | 0.465 |
| Total antagonist dose (mg) | 0.375 (0.125-0.5) | 0.5 (0.25-0.625) | <0.001 |
| rLH supplementation dose (IU) |
375 (150-900) | 300 (75-750) | <0.001 |
| Percentage of rLH supplementation |
561 (84.2%) | 614 (75.4%) | <0.001 |
| Hormone profile at trigger day | |||
| E2 (pg/mL) | 3614.13 ± 2118.49 | 3583.40 ± 2257.76 | 0.789 |
| P (ng/mL) | 0.91 ± 0.58 | 0.96 ± 0.69 | 0.229 |
| LH (IU/L) | 2.11 ± 1.01 | 3.13 ± 1.92 | <0.001 |
| Frequencies of LH below 1.2 IU/L | |||
| 0 | 268 (40.2%) | 495 (60.8%) | <0.001 |
| 1 | 224 (33.6%) | 246 (30.2%) | 0.161 |
| ≥2 | 174 (26.1%) | 73 (9.0%) | <0.001 |
| FORT a | 0.54 ± 0.25 | 0.52 ± 0.24 | 0.091 |
| IVF | 454 (68.2%) | 537 (66.0%) | 0.371 |
| ICSI or IVF - ICSI split | 212 (31.8%) | 277 (34.0%) | |
| Fertilization rate (IVF) | 0.62 ± 0.21 | 0.60 ± 0.24 | 0.069 |
| Fertilization rate (ICSI) | 0.74 ± 0.20 | 0.76 ± 0.21 | 0.256 |
| No. of oocytes retrieved | 14.46 ± 6.96 | 14.21 ± 7.17 | 0.492 |
| No. of MII oocytes | 9.84 ± 5.62 | 9.56 ± 5.56 | 0.589 |
| No. of good-quality embryos on day 3 | 4.29 ± 3.49 | 4.23 ± 3.50 | 0.769 |
| No. of total embryos available | 4.23 ± 2.41 | 4.18 ± 2.38 | 0.691 |
| Parameters of the first ET cycle | |||
| Fresh ET | 208 (31.2%) | 233 (28.6%) | 0.275 |
| Frozen-thawed ET | 458 (68.8%) | 581 (71.4%) | |
| Endometrial thickness | 9.56 ± 1.96 | 9.42 ± 1.87 | 0.162 |
| No. of embryos transferred | 1.95 ± 0.31 | 1.97 ± 0.32 | 0.316 |
| Cleavage embryos transferred | 599 (89.9%) | 731 (89.8%) | 0.931 |
| Blastocyst | 67 (10.1%) | 83 (10.2%) | |
Data are mean ± SD, median (IQR), or n (%). E2, estradiol; P, progesterone; rLH, recombinant LH; MII, metaphase II; ET, embryo transfer.
a
FORT= follicle output rate, calculated as the number of 16-22 mm preovulatory follicles/the number of 3-8 mm antral follicles on the third day of the menstrual cycle.