Figure 2.

Relationship between hormone-positive breast cancer and Klebsiella. (A) Klebsiella is abundant in the microbiomes of luminal A subtype breast cancer patients. Klebsiella was 5.58-fold more abundant in breast cancer patients, especially in luminal A subtype patients. (B) Klebsiella pneumonia EVs were extracted by mass culture and confirmed by transmission electron microscopy. The average diameter of a K pneumoniae EV was approximately 30 nm. (C) Frequency of Klebsiella microbiome in healthy control and patient groups. Patients were divided into 2 groups according to the frequency of the Klebsiella microbiome. (D) Comparison of alpha diversity between the healthy control group and patient group. (E) Comparison of beta diversity between the healthy control group and patient group. EVs = extracellular vesicles.