Table 3. QUADAS-2 assessments for studies in adults.

Study	Risk of bias				Applicability concerns
ADULTS	Patient selection	Index test	Reference standard	Flow and timing	Patient selection	Index test	Reference standard
Agostinis 2017 [34]	High	High	High	Unclear	High	Low	High
Babasa 2019 [35]	Low	Unclear	Unclear	Unclear	Low	Low	Low
Fentress 2020 [33]	High	High	Low	Unclear	High	Low	Low
Montuori 2019 [9]	High	Unclear	High	High	Low	Low	High
Wagih 2020 [36]	High	Unclear	High	High	High	Low	High

Low = low risk/concern; High = high risk/concern; Unclear = unclear risk/concern.