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. 2021 May 7;20:99. doi: 10.1186/s12933-021-01286-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — ACE2 immunofluorescence detection. a Representative images of ACE2 expression (red) and cardiac troponin T (green) in non-COVID-19 and COVID-19 heart tissue from patients with diabetes (DM) and patients without diabetes (Non-DM). Cell nuclei were stained blue with DAPI. b Fluorescence intensity analysis in the Non-DM Non-COVID-19 (n = 43) versus DM Non-COVID-19 (n = 7), (p = 0.0032) and Non-DM COVID-19 (n = 17) versus DM COVID-19 (n = 30), (p = 0.009) of myocardial ACE2 expression was estimated with Image J software. Analysis comparing DM COVID-19 versus Non-DM Non-COVID-19 (p = 8.96865E−05) and DM COVID-19 versus DM Non-COVID-19 (p = 1.10E−04) was also reported. Shown as mean ± SD. Statistical test: Student’s t-test. Bonferroni correction was used to make pairwise comparisons. Data were presented as box and whisker plots showing medians (middle line) and in boxes the third and first quartiles (75th and 25th percentiles), while the whiskers show 1.5 × the interquartile range (IQR) above and below the box. Scale bar = 10 µm. ACE2 angiotensin-converting enzyme 2