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Schematic representation of the proposed effect of diabetes milieu on ACE2 in the heart of patients with type 2 diabetes. In patients with diabetes, the enhanced long-term non-enzymatic glycation of ACE2 at the neck domain of dimerization can affect ACE2 oligomerization and, consequently, its avidity for SARS-COV-2 Spike binding, potentially favoring cardiomyocyte virus entry
