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. 2021 May 7;7(19):eabe5171. doi: 10.1126/sciadv.abe5171

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Fig. 5 — (A and B) Immunoblotting analysis of α-mannan–induced interaction of c-Cbl and RelB overexpressed in HEK293T as the indicated combinations. (C and D) Immunoblotting analysis of the interaction of c-Cbl and RelB in BMDCs after stimulation with α-mannans (C) or C. albicans hyphae (D) as indicated. (E) Immunoblotting analysis of α-mannan–induced interaction of c-Cbl and RelB in BMDCs with or without pretreatment of Syk inhibitor R406. (F) Immunoblotting analysis of α-mannan–induced ubiquitination of RelB in BMDCs from Cbl^f/fCD11c^Cre/+ and c-Cbl^f/f mice. (G and H) Immunoblotting analysis of the ubiquitination of RelB overexpressed in HEK293T with the indicated combinations. (I and J) Immunoblotting analysis of α-mannan–induced degradation of RelB in BMDCs from Cbl^f/fCD11c^Cre/+ and c-Cbl^f/f mice (I) or wild-type (Clec4n^+/+) and Dectin-2 knockout (Clec4n^−/−) mice (J).