Table 3.

Correlation of EV parameters with clinical and biochemical patient characteristics

Variable	Age (years)	pO2 (KPa)	Lactic acid (mmol/L)	D-dimer (mg/L)	PT-INR (a.u.)	aPTT (sec)	C-reactive protein (mg/L)	WBC (*10E9/L)	Hosp (days)
CD9-63-81 (MFI)	−0.097	−0.440	0.031	−0.134	−0.176	−0.152	0.300	−0.403	−0.062
	0.434	0.015	0.897	0.595	0.370	0.500	0.096	0.018	0.637
CD86 (nMFI; %)	0.180	−0.044	0.201	−0.096	−0.283	0.003	−0.015	−0.373	0.179
	0.144	0.816	0.394	0.705	0.144	0.991	0.936	0.030	0.167
CD133/1 (nMFI; %)	−0.107	−0.141	−0.030	−0.056	−0.381	0.008	−0.205	−0.338	0.141
	0.389	0.458	0.899	0.826	0.055	0.972	0.260	0.051	0.280
CD69 (nMFI; %)	−0.034	−0.166	0.109	−0.133	−0.272	−0.336	−0.031	−0.222	0.252
	0.788	0.379	0.646	0.598	0.162	0.127	0.866	0.207	0.050
CD20 (nMFI; %)	0.130	−0.118	0.200	−0.039	−0.365	−0.053	−0.141	−0.293	0.082
	0.296	0.533	0.398	0.877	0.056	0.814	0.440	0.093	0.529
CD142 (nMFI; %)	−0.106	−0.086	0.144	0.007	−0.288	−0.006	−0.214	−0.480	0.162
	0.393	0.653	0.544	0.977	0.137	0.978	0.240	0.004	0.211
CD142-WB (a.u.)	0.128	−0.465	0.146	0.042	0.197	0.590	0.133	−0.429	0.455
	0.550	0.029	0.634	0.897	0.406	0.010	0.546	0.041	0.025
CD142 activity (pM)	−0.109	−0.219	−0.013	0.039	−0.022	0.225	−0.127	−0.288	0.004
	0.382	0.244	0.957	0.877	0.913	0.315	0.487	0.099	0.976
TNF-α (pg/mL)	−0.180	−0.199	−0.020	−0.054	0.235	0.181	0.154	−0.268	0.052
	0.144	0.293	0.935	0.832	0.228	0.420	0.400	0.125	0.693

Correlations between clinical/biochemical patient characteristics and EV parameters (EV surface antigens differentially expressed in patients diagnosed as pneumonia, with or without infection by SARS-CoV-2; CD142 activity and TNF-α assessed by ELISA; CD142 quantification by WB, CD142-WB; n = 28). Correlations are evaluated by Spearman's Rho test. Spearman's Rho coefficient (above) and P-values (below) are reported for each analysis. P-values of less than 0.05 were considered significant and are reported in bold.