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. 2021 May 7;10:e64711. doi: 10.7554/eLife.64711

Figure 4. Tumor spheroids with sera from P. polionotus and P. maniculatus.

Morphology of tumor spheroids formed after 2, 3, and 7 days in culture with sera isolated from monogamous P. polionotus and polygamous P. maniculatus. In 6 of 12 P. polionotus but none of 12 P. maniculatus enhanced dispersion was noted at bond disruption. For the experiment, sera were obtained from the same animal at bonding for 12 months and after 1 week following bond disruption. Bond-disrupted animals were housed independently after separation from females. BW B, P. maniculatus bonded; BW BD, P. maniculatus bond-disrupted; PO B, P. polionotus bonded; PO BD, P. polionotus bond disrupted.

Figure 4.

Figure 4—figure supplement 1. Microsphere morphology of A549 human lung cancer cells cultured in P. maniculatus or P. polionotus sera.

Figure 4—figure supplement 1.