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. 2021 May 3;8:333–348. doi: 10.2147/JHC.S306484

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© 2021 Zhang et al.

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CCDC144NL-AS1 promotes invasion and proliferation, while inhibited apoptosis of HCC cells. (A) CCDC144NL-AS1 expression was highest in HCC cell line MHCC97H compared to other HCC cell lines and normal hepatic cell line L02. (B) The expression of CCDC144NL-AS1 is located in both cytoplasm and nucleus of cells. (C and D) Knockdown of CCDC144NL-AS1 markedly inhibited the invasion and proliferation abilities, and enhanced the level of late apoptosis in MHCC97H cells, while overexpressing CCDC144NL-AS1 enhanced the invasion and proliferation abilities, and inhibited the level of late apoptosis in L02 cells. (E) Knockdown of CCDC144NL-AS1 led to decreased Ki67 expression in MHCC97H, while overexpressing CCDC144NL-AS1 increased Ki67 expression in L02. (F) Detection of migration-related proteins showed that there’s no significant change in their expression levels. The scale bar is 50 um. Data were expressed as mean ± SEM. *P<0.05, **P<0.001.