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. 2021 May 7;2021(5):CD010876. doi: 10.1002/14651858.CD010876.pub3

Comparison 1. Exercise versus no exercise.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1.1 All‐cause mortality at longest follow‐up 2 131 Risk Ratio (M‐H, Fixed, 95% CI) 0.83 [0.26, 2.68]
1.2 All‐cause mortality: best/worst‐case scenario 2 131 Risk Ratio (M‐H, Fixed, 95% CI) 0.44 [0.15, 1.32]
1.3 All‐cause mortality: worst/best‐case scenario 2 131 Risk Ratio (M‐H, Random, 95% CI) 2.15 [0.16, 28.78]
1.4 All‐cause hospitalisation at longest follow‐up 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
1.5 HRQoL (mental component) at end of intervention 2 150 Mean Difference (IV, Fixed, 95% CI) 1.28 [‐1.60, 4.16]
1.6 HRQoL (physical component) at end of intervention 2 150 Mean Difference (IV, Random, 95% CI) 2.99 [‐5.24, 11.21]
1.7 HRQoL (mental component) at maximum follow‐up 2 139 Mean Difference (IV, Fixed, 95% CI) ‐1.45 [‐4.70, 1.80]
1.8 HRQoL (physical component) at maximum follow‐up 2 139 Mean Difference (IV, Fixed, 95% CI) ‐0.87 [‐3.57, 1.83]
1.9 Exercise capacity (direct: VO2 max) at end of intervention 4 250 Mean Difference (IV, Fixed, 95% CI) 2.38 [0.36, 4.40]
1.10 Exercise capacity (direct: VO2 max) at longest follow‐up 4 240 Mean Difference (IV, Fixed, 95% CI) 1.53 [‐0.44, 3.50]
1.11 Exercise capacity (maximum measures) at end of Intervention 5 294 Std. Mean Difference (IV, Fixed, 95% CI) 0.38 [0.15, 0.61]
1.12 Exercise capacity (maximum measures) at longest follow‐up 5 284 Std. Mean Difference (IV, Fixed, 95% CI) 0.37 [0.13, 0.61]
1.13 Exercise capacity (indirect/submaximal: 6MWT) at end of Intervention 3 167 Mean Difference (IV, Random, 95% CI) ‐3.89 [‐58.72, 50.95]
1.14 Exercise capacity (indirect/submaximal: 6MWT) at longest follow‐up 3 157 Mean Difference (IV, Random, 95% CI) ‐25.48 [‐103.04, 52.08]
1.15 Serious adverse events 4 326 Risk Ratio (M‐H, Fixed, 95% CI) 1.07 [0.50, 2.27]
1.16 Return to work 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected