PREPARE TAVR Pilot Study.

Study name	Physiological reconditioning program administered remotely in patients undergoing transcatheter aortic valve replacement pilot study
Methods	Parallel‐assignment RCT
Participants	Frail adults undergoing transcatheter aortic valve replacement (TAVR) procedures
Interventions	Patients assigned to intervention arm will be provided a personalised, tailored, and graduated exercise programme to improve physical strength and conditioning
Outcomes	Primary Quality of life (QoL) [Time Frame: 1 year] Quality of life as assessed by the Kansas City Cardiomyopathy Questionnaire (KCCQ). KCCQE is a 23‐item self‐administered questionnaire developed to independently measure patients' perceptions of their health status, which includes heart failure symptoms, impact on physical and social function, and how their heart failure impacts their quality of life (QoL) within a 2‐week recall period. KCCQ responses are provided along a rating scale continuum with equal spacing from worst to best Secondary LOS [Time Frame: index hospitalisation, length of stay post TAVR] MACE [Time Frame: 1 year, composite of mortality and repeat hospitalisation]
Starting date	1 February 2019
Contact information	Syed Ishba; syedi@smh.ca
Notes	Estimated enrolment: 160 participants. Estimated study finish date: 31 March 2021 Location: St. Michael's Hospital, Toronto