Effect of changes in mortality risk ratio on model outcome.
Arrows indicate the risk ratios of different patient subgroups. The shaded region demarcates the risk ratio range over which ICD dominates CRT-D. CRT-D = cardiac resynchronization therapy combined with an ICD; ICD = implantable cardioverter-defibrillator; LBBB = left bundle branch block; MADIT-CRT = Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy; NYHA = New York Heart Association class; QALY = quality-adjusted life-year; RAFT = Resynchronization-Defibrillation for Ambulatory Heart Failure Trial; RR = risk ratio.
* Subgroups in which there is a non–statistically significant change in relative risk.