Appendix Figure 1.

Survival curves for model cohorts.

The dashed line represents the survival curve for patients receiving CRT-D, and the dotted line the survival in patients receiving an ICD (in the current study cohort). In MADIT-CRT, 92.7% of patients receiving an ICD and 93.2% of those receiving CRT-D were alive after a mean follow-up of 29 months. In RAFT, 78.9% of patients receiving an ICD and 84.5% of those receiving CRT-D were alive after a mean follow-up of 40 months. Model survival curves are in essence Kaplan–Meier curves, assuming sampling without replacement. However, the survival estimates from the published studies are based on the mean follow-up time and the total number of deaths and thus assume sampling with replacement. CRT-D = cardiac resynchronization therapy combined with an ICD; ICD = implantable cardioverter-defibrillator; MADIT-II = Multicenter Automatic Defibrillator Implantation Trial II; MADIT-CRT = Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy; RAFT = Resynchronization-Defibrillation for Ambulatory Heart Failure Trial.