Table 2.
Effect sizes (hazard ratios) and the 95% confidence intervals fitted using a multivariate Cox proportional hazard (PH) model in the CGS.
| Gene annotation | Predictor | Hazard ratio | 95% CI |
|---|---|---|---|
| CFTR | CFTR variant score | 3.02 | (2.01, 4.54) |
| – | Sex (female) | 1.48 | (1.26, 1.74) |
| SLC5A8 | rs12318809 (G) | 1.35 | (1.16, 1.57) |
| CAV1 | rs959173(C) | 1.27 | (1.10, 1.47) |
| PRSS1 | rs1964986(C) | 1.23 | (1.09, 1.38) |
| SLC26A9 | rs4077468 (A) | 1.20 | (1.07, 1.34) |
| NRG1 | rs7822917 (T) | 1.31 | (1.16, 1.48) |
| – | Meconium ileus (MI) | 1.29 | (1.05, 1.59) |
| TCF7L2 | rs7903146 (T) | 1.18 | (1.05, 1.34) |
CGS Canadian Cystic Fibrosis Gene Modifier Study, CI confidence interval.
Risk allele/risk group noted in parentheses after the listed predictor.