Table I.
Characteristics of 3 cases of drug-induced subacute cutaneous lupus erythematosus induced by proton pump inhibitors and antihypertensive agents in patients previously diagnosed with systemic lupus erythematosus
| Characteristics | Case 1 | Case 2 | Case 3 |
|---|---|---|---|
| Age and sex | 65 y/o F | 74 y/o F | 66 y/o F |
| Number of years the patient had SLE | 33 | 30 | 8 |
| Prior cutaneous involvement? | Yes, acute LE | Yes, discoid LE | No |
| Offending medication | Hydrochlorothiazide | Amlodipine and/or omeprazole | Pantoprazole |
| Drug-induced cutaneous pattern | SCLE | SCLE | SCLE |
| Supporting biopsy of cutaneous lupus after medication? | Yes | No | Yes |
| Incubation time | Approximately 1 year | 3 months | 2 months |
| Outcome | Resolved after stopping the medication and adding hydroxychloroquine | Resolved after stopping the medication and adding quinacrine | Resolved after stopping the medication |
F, Female; LE, lupus erythematosus; SCLE, cutaneous systemic lupus erythematosus; SLE, systemic lupus erythematosus; y/o, years old.