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. 2021 Mar 18;16(3):309–324. doi: 10.1007/s11523-021-00795-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Clonal tracking with liquid biopsy (LB) in patients with metastatic colorectal cancer (mCRC) receiving active treatment. After mCRC diagnosis (1), the collection of blood samples for LB (2,3) allows the detection of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) (4). Their analysis provides useful information for molecular profiling and treatment selection; additionally, CTCs can be employed for culturing and xenografting, thus adding relevant data of tumor sensitivity to the selected treatment (5). Given the high feasibility of LB, new blood samples are then collected during active treatment, to monitor the emergence of resistance through clonal tracking (6). Created with BioRender.com