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. Author manuscript; available in PMC: 2022 Jun 1.
Published in final edited form as: Mol Imaging Biol. 2021 Jan 7;23(3):323–334. doi: 10.1007/s11307-020-01570-0

Figure 3.

Figure 3.

Biochemical scheme illustrating the metabolic pathway of converting HP [1-13C] pyruvate to HP [1-13C] lactate and HP [1-13C] alanine, and increased HP [1-13C] lactate export into the TME via the upregulated MCT4.