Table 2.
Level and annual changes of HDL metrics by time relative to the final menstrual period
| HDL metric | Premenopause stage* | Perimenopause stage* | Postmenopause stage* | |||
|---|---|---|---|---|---|---|
| At stage start | During stage | At stage start | During stage | At stage start | During stage | |
| Mean (SD) | Annual change(SE) † | Mean (SD) | Annual change(SE) † | Mean (SD) | Annual change(SE) † | |
| HDL-C, mg/dL | 60.37(14.44) | 0.92 (0.24) | 62.04(15.75) | 0.08(0.41) | 62.75(15.56) | 0.41(0.12) |
| Large HDL-P NMR, umol/L | 8.9(3.54) | 0.20(0.06) § | 9.0(3.91) | −0.31(0.10) | 8.75(4.02) | 0.12(0.03) § |
| Medium HDL-P NMR, umol/L | 11.34(6.05) | 0.07(0.12) | 11.73(6.02) | 0.14(0.33) | 11.28(5.69) | −0.11(0.07) |
| Small HDL-P NMR, umol/L | 14.25(6.78) | 0.05(0.14) § | 15.92(6.96) | 0.82(0.22) | 16.71(6.8) | 0.04(0.08) § |
| HDL size NMR †, nm | 9.6(0.52) | 0.02(0.01) § | 9.56(0.55) | −0.07(0.01) | 9.32(0.54) | 0.01(0.01) § |
| HDL-CEC % | 4(0.69) | 0.04(0.01) | 4.07(0.65) | −0.0003(0.02) | 4.08(0.67) | 0.01(0.01) |
| HDL metric | Pre-/Perimenopause stage* | Postmenopause stage* | ||||
| Mean (SD) | Annual change(SE) † | Mean (SD) | Annual change(SE) † | |||
| apoA1, mg/dl | 163.52(26.06) | 1.52(0.39) ‡ | 167(31.36) | −0.97(0.21) | ||
| Total HDL-P NMR , umol/L | 34.58(5.7) | 0.48(0.09) ‡ | 36.36(6.37) | 0.18(0.04) | ||
| HDL-PL, mg/dL | 54.53(10.26) | 0.59(0.16) ‡ | 55.81(11.46) | 0.12(0.06) | ||
| HDL-Tg (log transformed), mg/dl | 18.16(5.75) | 0.005(0.003) | 19.02(5.79) | 0.01(0.003) | ||
| CEC% / Total HDL-P NMR | 0.12(0.02) | −0.001(0.0003) | 0.11(0.02) | −0.0002(0.0002) | ||
Menopause stages were identified based on the following cut points of years relative to the FMP for each HDL metric as identified by LOESS plots: HDL metrics with 3-4 segments [HDL-C: −0.5, 1.5; Large HDL-P: −0.5, 1.5; Medium HDL-P: 0, 1.5; Small HDL-P: −0.5, 2; HDL size: −0.5, 2, 5; HDL-CEC%: −0.5, 1.5]; HDL metrics with 2 segments [apoA1: 0.5; Total HDL-P: 0; HDL-PL: −0.5; HDL-Tg: 2; CEC% / Total HDL-P: 1.5]. Bold indicates significantly differ from zero at P ≤0.05.
Models adjusted for age at FMP, study site and race/ethnic group. Annual change in the fourth segment for HDL size was not significant and was not significantly differ from annual change in segment 3
Significantly differs from postmenopause stage
Significantly differ from perimenopause stage
apoA1: apolipoprotein A1; FMP: final menstrual period; HDL-C: high-density lipoprotein cholesterol; HDL-CEC: high-density lipoprotein cholesterol efflux capacity; HDL-P: high-density lipoprotein particles; HDL-PL: high-density lipoprotein phospholipids; HDL-Tg: high-density lipoprotein triglycerides.