Table 3.

Longitudinal associations of HDL conventional and composition metrics with HDL-CEC%

HDL metrics	HDL-CEC%
	Unadjusted		Adjusted*
	β(SE)	P value	β(SE)	P value
HDL-C, mg/dL	0.027(0.0010)	<.0001	0.027(0.001)	<.0001
apoA1, mg/dl	0.012(0.0005)	<.0001	0.011 (0.0006)	<.0001
Total HDL-P , umol/L	0.044(0.002)	<.0001	0.040(0.003)	<.0001
Large HDL-P, umol/L	0.088(0.004)	<.0001	0.093(0.005)	<.0001
Medium HDL-P, umol/L	0.023(0.002)	<.0001	0.021(0.003)	<.0001
Small HDL-P, umol/L	−0.005(0.002)	0.0239	−0.007(0.002)	0.005
HDL size, nm	0.403(0.033)	<.0001	0.437(0.037)	<.0001
HDL-PL, mg/dL	0.040(0.001)	<.0001	0.040(0.001)	<.0001
HDL-Tg, mg/dL †	0.480(0.052)	<.0001	0.524(0.055)	<.0001

^*Adjusted for study site, race/ethnicity, segment indicator, time varying age, body mass index, and C3

^†Log transformed

apoA1: apolipoprotein A1; HDL-C: high-density lipoprotein cholesterol; HDL-CEC: high-density lipoprotein cholesterol efflux capacity; HDL-P: high-density lipoprotein particles; HDL-PL: high-density lipoprotein phospholipids; HDL-Tg: high-density lipoprotein triglycerides.