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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Dec 10;41(2):668–682. doi: 10.1161/ATVBAHA.120.315109

Fig. 7. TPI is a quick-acting anti-thrombotic drug that reduces the effective dose of tPA on preventing occlusive thrombi formation.

Fig. 7.

Thrombosis in female WT mice were initiated with 7.5% FeCl3 and 5 min later, TPI (A), tPA (B), or the combination of TPI and tPA (C) in saline at the indicated doses were bolus injected into mice through a jugular vein catheter, and thrombosis times were assessed. D. Representative images for mice received 0.25 mg/kg tPA and 0.075 mg/kg TPI bolus injection are shown.