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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2020 Dec 17;41(2):822–836. doi: 10.1161/ATVBAHA.120.315053

Figure 7. Vascular permeability is increased along the margins of atherosclerotic plaques where CXCR4-expressing ECs proliferate.

Figure 7.

(A) Bright field (upper) and fluorescent (bottom) stereoscope images of an aortic arch (left) and plaques in a descending aorta (right) from Apoe−/− mice injected 200 μL of 0.5% Evans blue. Scale bar: 1 mm (left) and 500 μm (right) (B) CXCR4 distribution in a plaque of Apoe−/− mice injected evans blue. Yellow lines indicate the edged of the plaque. Scale bar: 200 μm (C) Ki-67 and CXCR4 distribution in atherosclerotic plaques at an aortic arch with low (middle) and high (left and right) magnification. Yellow lines indicate the edged of the plaque. Scale bar: 200 μm (middle) and 50 μm (left and right). (D) The scheme for gating of Ki-67 or CXCR4 positive ECs. (E) The percentage of Ki-67 positive cells in CXCR4 positive or negative ECs (n=6 per group). Data are shown as means ± SEM. ***p<0.001 by paired t test.