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. 2021 May 7;11:9803. doi: 10.1038/s41598-021-89379-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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γS inhibition targets endogenous ACE2. (A) Western blots of Caco-2 cells treated with DBZ ( +) or DMSO (−). (ns) indicates non-specific bands. (B) Western blots of VeroE6 cells treated with DBZ ( +) or DMSO (−). (C) Western blots of VeroE6 cells treated with DBZ compound E (CmpE) or DMSO (−). D, Gene expression in VeroE6after 24 or 72 h treatment with DBZ, showing means ± SD. (E) Gene expression in Caco-2 cells after 24 or 72 h treatment with DBZ, showing means ± SD.