Table 1.
Descriptive statistics of patient characteristics for all pediatric aortic valve (AV) tissue samples featured in the study.
| SKU | Age (years) | Pediatric age group | Gender | Race/ethnicity | BSA (m2) | Leaflet morphology | Aortic valve function |
|---|---|---|---|---|---|---|---|
| Normal | |||||||
| DB017 | 0.5 | Infant | M | – | 0.38 | Trileaflet | Normal |
| DB051 | 0.66 | Infant | M | C | 0.34 | Trileaflet | Normal |
| NDRI | 2 | Young child | M | L | 0.63 | Trileaflet | Not recorded |
| DB85 | 9 | Child | F | C | 0.95 | Trileaflet | Normal |
| DB27 | 17 | Adolescent | M | C | 2.2 | Trileaflet | Normal |
| Normal Averages | 7.17 ± 7.5 | 75%M 25%F | 75%C 25%L | 1.03 | |||
| pCAVS | |||||||
| DB106 | 0.04 | Neonate | M | C | 0.21 | Bicuspid | Severe stenosis with AVI |
| DB43 | 0.15 | Infant | M | C | 0.24 | Trileaflet | Moderate stenosis with AVI* |
| DB40 | 0.75 | Infant | M | C | 0.37 | Bicuspid | Moderate stenosis |
| DB105 | 5 | Young child | M | C | 0.72 | Bicuspid | Moderate stenosis with AVI |
| DB119 | 5 | Young child | F | – | – | Bicuspid | Moderate stenosis with AVI |
| DB113 | 5 | Young child | – | – | – | – | Trivial stenosis; severe AVI |
| DB18 | 6 | Child | F | C | 0.7 | Bicuspid | Moderate stenosis with AVI |
| DB3 | 11 | Child | F | C | 1.5 | Bicuspid | Moderate stenosis with AVI |
| DB117 | 12 | Adolescent | M | – | Bicuspid | Moderate stenosis with AVI | |
| DB41 | 14 | Adolescent | M | C | 1.6 | Bicuspid | Moderate stenosis with AVI |
| DB16 | 17 | Adolescent | M | C | 2.1 | Bicuspid | Moderate stenosis with AVI |
| pCAVS Averages | 6.90 ± 5.8 | 70%M 30%F | 100%C | 0.93 | |||
| AVI | |||||||
| DB114 | 0.17 | Infant | F | – | – | Trileaflet | Trivial AVI |
| DB007 | 0.58 | Infant | – | – | – | Trileaflet | Mild nAVI |
| DB108 | 10 | Child | F | C | 1.3 | Trileaflet | Thickened with AVI |
| DB83 | 10 | Child | F | AA | 1.4 | Trileaflet | Trivial AVI |
| DB032 | 16 | Adolescent | – | – | – | Trileaflet | Mild nAVI |
| AVI Averages | 7.35 ± 6.8 | – | – | 1.35 | |||
Normal AVs are from cardiac transplant patients where normal AV function is define by 2D echocardiogram. 2D Echocardiogram mean gradients define pre-operative AV function where a normal gradient is defined as < 5 mmHg, mild stenosis as 5–25 mmHg, moderate stenosis as 25–50 mmHg, and severe stenosis as > 50 mmHg. BSA: body surface area; C: Caucasian; L: Latino; AA: African American; MD: Myxomatous Degeneration. DB43 was included in pCAVS due to stenosis, but main diagnosis was Hypertrophic Cardiomyopathy. Pediatric Age Groups are defined by National Institute of Child and Human Development: Neonate (0–30d), Infant (1 mo–2yrs), young Child (2–6 yrs), Child (6–12 yrs), Adolescent (12–18 yrs). Experiment information can be seen in Supplemental Table S5.