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. 2021 May 7;11:9766. doi: 10.1038/s41598-021-89137-z

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Showing results of targeted metabolomics analysis of aqueous humor in POAG compared to controls. (a) Heat map of metabolomic analysis of control and POAG patient cohort. (b) List of pathways to which significant differential metabolites belong to POAG are binned at an FDR of 0.25. (c) Unbiased PLS-DA clustered the samples into two different group is represented by a score plot (d) showing Random Forest analysis distinguishing POAG from controls (e) showing overlap of metabolic pathways with transcriptomic data set (GSE27276 and GSE4316) using KEGG (f) Comparative analysis of proteomic data (Literature) with metabolomic data (present study) showing one conserved pathway. (g) showing overlap of 21 pathways between metabolomics data (present study) and metabolomics (Literature) (h) Flower model Venn diagram showing overlapping pathways among metabolomics data from present study and those from Literature. (a,c,d) was generated using MetaboAnalyst 5.0 (Version-5.0; URL link: https://www.metaboanalyst.ca/). (e–h) was created using VENNY^2.1 (Version-2.1; URL link: https://bioinfogp.cnb.csic.es/tools/venny/).