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. 2021 May 7;11:9766. doi: 10.1038/s41598-021-89137-z

Figure 6.

Figure 6

ATP and DMAG induced tryptophan pathway gene expression and their modulation by BAPTA, NEM and SNP respectively. Showing ATP (25 μM or 100 μM) treated N9 cells or those pre-incubated with BAPTA (50 μM) before treating with ATP showing (a) IDO-1 (b) IDO-2 (c) TDO-2. DMAG (1 mM) treated N9 cells with or without pre-incubation with NEM (1 μM) (d) IDO-1 (e) TDO-2. DMAG (1 mM) treated N9 cells with or without pre-incubation with SNP (0.5 mM) (f) IDO-1 (g) IDO-2 (h) TDO-2. DMAG (1 mM) treated N9 cells with or without pre-incubation with BAPTA (50 μM) (i) IDO-1 (j) IDO-2. (k) Showing overall mechanism. The significance was calculated using Student T-test. *for P < 0.05, ** for P < 0.01, and *** for P < 0.001. For n numbers and the results provided as mean ± SEM, refer to text. Figure 6 k was created using Microsoft office Professional Plus 2016 (version-2016).