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. 2021 May 7;4:78. doi: 10.1038/s41746-021-00445-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Shows that active substance abuse yields a negative contribution. Center line and box limits correspond to median and upper and lower quartiles, respectively. b Shows the difference in age distribution between active substance abusers and others. c Shows difference in the predicted risk scores of the test population if the active substance abuse value is set zero or one.