Table 2.
Primary and Secondary Analyses Results
| Whole Cohort (N = 149) | Seropositive (n = 74) | Seronegative (n = 75) | p Value | |
|---|---|---|---|---|
| Blood pressure | ||||
| Peripheral sBP, mm Hg | 119 (109–130) | 115 (109–130) | 121 (110–131) | 0.3 |
| Peripheral dBP, mm Hg | 75 ± 9 | 74 ± 9 | 75 ± 10 | 0.58 |
| Laboratory investigations | ||||
| Hs troponin T (normal <14) | 4 (3–7) | 4 (3–7) | 4 (3–7) | 0.57 |
| NT-proBNP (normal <400) | 31 (18–54) | 36 (18–53) | 28 (17–56) | 0.24 |
| Function | ||||
| LVEF, % | 67.1 (63.7–70.1) | 67.5 (64.4–70.2) | 66.8 (62.8–70.1) | 0.28∗ |
| GLS mean, % | 17.4 ± 2.1 | 17.5 ± 1.8 | 17.3 ± 2.4 | 0.62† |
| Structure | ||||
| LVEDV indexed, ml/m2 | 78.8 (70.2–90.9) | 78.1 (69.7–90.3) | 80.0 (71.3–94.9) | 0.37∗ |
| LA area indexed, ml/m2 | 12.0 (10.9–13.1) | 12.0 (11.0–13.2) | 11.9 (10.6–13.1) | 0.87† |
| LV mass index, g/m2 | 46.6 (41.2–56.7) | 47.5 (41.5–57.6) | 47.5 (41.5–56.7) | 0.56† |
| Tissue characterization | ||||
| LGE, % | 0.29 ± 0.86 | 0.27 ± 0.78 | 0.32 ± 0.93 | 0.72∗ |
| RV insertion point | 14 (9) | 8 (11) | 6 (8) | 0.56 |
| Non-RV insertion point | 13 (9) | 6 (8) | 7 (9) | 0.79 |
| T1 septum, ms | 1,018 ± 31 | 1,020 ± 34 | 1,016 ± 28 | 0.42∗ |
| High | 6 (4) | 5 (7) | 1 (1) | 0.12 |
| T1 global, ms | 1,009 ± 27 | 1,010 ± 28 | 1,007 ± 25 | 0.47 |
| High | 6 (4) | 4 (5) | 2 (3) | 0.44 |
| T2 septum, ms | 48.7 ± 2.2 | 48.8 ± 2.5 | 48.6 ± 1.9 | 0.63∗ |
| High | 9 (6) | 7 (9) | 2 (3) | 0.098 |
| T2 global, ms | 48.6 ± 1.9 | 48.7 ± 1.9 | 48.4 ± 1.9 | 0.3 |
| High | 7 (5) | 4 (5) | 3 (4) | 0.72 |
| ECV septal, % | 22.2 ± 2.1 | 22.3 ± 2.0 | 22.1 ± 2.2 | 0.57† |
| High | 5 (3) | 3 (4) | 2 (3) | 0.68 |
| ECV global, % | 21.5 ± 2.0 | 21.6 ± 1.9 | 21.5 ± 2.1 | 0.73 |
| High | 4 (3) | 3 (4) | 1 (1) | 0.37 |
| Aortic stiffness | ||||
| Distensibility, mmHg-1·10-3 | 12.3 (8.7–17.5) | 12.6 (9.1–18.3) | 12.0 (8.7–17.1) | 0.74† |
Values are median (interquartile range), mean ± SD, or n (%). NT-proBNP in pg/ml and hs-troponin T in ng/ml. All indexing is to body surface area.
BSA = body surface area; COPD = chronic obstructive pulmonary disease; dBP = diastolic blood pressure; ECV = extracellular volume fraction; EDV = end-diastolic volume; EF = ejection fraction; GLS = global longitudinal shortening; IQR = interquartile range; LGE = late gadolinium enhancement; LV = left ventricle; LVM = left ventricular mass; NT-proBNP = N-terminal pro-brain natriuretic peptide; RV = right ventricular; sBP = systolic blood pressure.
∗
Pre-specified primary endpoint.
†
Pre-specified secondary endpoint.