Table 2.
| Variable | Age <65 y (N=62) | Age 65-79 y (N=85) | Age ≥80 y (N=110) | P value |
|---|---|---|---|---|
| Symptoms/signsc | ||||
| RUQ/epigastric pain | 56 (90.3) | 76 (89.4) | 71 (64.5) | <.001 |
| Jaundice | 31 (50.0) | 38 (44.7) | 40 (36.4) | .193 |
| Fever | 31 (50.0) | 42 (49.4) | 46 (41.8) | .458 |
| Unwell or fatigued | 23 (37.1) | 58 (68.2) | 81 (73.6) | <.001 |
| Tmax, °C | ||||
| <38 | 31 (50.0) | 46 (54.1) | 69 (62.7) | .240 |
| 38-39 | 21 (33.9) | 22 (25.9) | 30 (27.3) | .504 |
| 39-40 | 9 (14.5) | 15 (17.6) | 7 (6.4) | .062 |
| >40 | 1 (1.6) | 2 (2.4) | 4 (3.6) | .342 |
| Altered mental status | 3 (4.8) | 14 (16.5) | 37 (33.6) | <.001 |
| SBP <100 mm Hg | 13 (21.0) | 27 (31.8) | 43 (39.4) | .045 |
| Respiratory rate >20/min | 29 (46.8) | 42 (49.4) | 62 (56.9) | .378 |
| Heart rate >90 bpm | 40 (64.5) | 43 (50.6) | 58 (52.7) | .206 |
| Laboratory findingsc | ||||
| White blood cell count (×109/L) | .036 | |||
| Median (Q1, Q3) | 12.1 (9.1, 15.0) | 12.5 (8.9, 15.2) | 13.2 (9.1, 18.6) | |
| Mean ± SD | 12.3±5.0 | 12.9±6.1 | 14.7±7.4 | |
| Range | 3.1-31.4 | 2.4-39.2 | 1.0-38.0 | |
| AST (IU/L) | .359 | |||
| Median (Q1, Q3) | 219 (127, 365) | 169 (100, 288) | 172.5 (98, 344.5) | |
| Mean ± SD | 309.1±325.7 | 244.6±239.4 | 291.6±303.6 | |
| Range | 18-2169 | 19-1276 | 17-1388 | |
| ALT (IU/L) | .040 | |||
| Median (Q1, Q3) | 278 (166.5, 390) | 162 (108, 318) | 218 (102, 404.5) | |
| Mean ± SD | 321.2±265.2 | 220.4±164.4 | 299.2±296.6 | |
| Range | 22-1354 | 19-682 | 10-1903 | |
| Alkaline phosphatase (IU/L) | .296 | |||
| Median (Q1, Q3) | 210.5 (144, 365) | 225 (144, 369) | 221 (146.5, 340) | |
| Mean ± SD | 269.0±162.9 | 315.2±277.5 | 270.8±187.5 | |
| Range | 80-759 | 50-1671 | 40-1196 | |
| Total bilirubin (mg/dL) | .329 | |||
| Median (Q1, Q3) | 3.7 (2.1, 5.9) | 3.0 (1.8, 4.7) | 3.7 (2.0, 4.7) | |
| Mean ± SD | 4.2±2.8 | 3.5±2.2 | 3.9±3.0 | |
| Range | 0.4-15.5 | 0.5-13.0 | 0.2-25.7 | |
| Direct bilirubin (mg/dL) | .384 | |||
| Median (Q1, Q3) | 3.2 (1.4, 4.7) | 3.0 (1.3, 4.2) | 2.5 (1.2, 3.6) | |
| Mean ± SD | 3.4±2.2 | 3.1±2.1 | 3.0±3.0 | |
| Range | 0.2-9.3 | 0.2-11.4 | 0.1-25.1 | |
| Positive blood cultures | 19 (30.6) | 41 (48.2) | 58 (52.7) | .018 |
| Imaging/ERCP findingsd | ||||
| Biliary dilatation | 43 (69.4) | 59 (69.4) | 86 (78.2) | |
| Only CT | 10 | 25 | 42 | .290 |
| Only US | 23 | 22 | 26 | |
| US + CT | 10 | 12 | 18 | |
| Common bile duct stone | 15 (24.2) | 33 (38.8) | 63 (57.3) | <.001 |
| Only CT | 10 | 21 | 39 | |
| Only US | 5 | 7 | 19 | |
| US + CT | 0 | 5 | 5 | |
| ERCP findings | ||||
| Sludge | 1 (1.6) | 4 (4.7) | 2 (1.8) | .504 |
| CBD stone/recent passing | 40 (64.5) | 62 (72.9) | 75 (68.2) | .143 |
| Pus | 1 (1.6) | 0 (0.0) | 2 (1.8) | .386 |
| CBD stone/sludge and pus | 20 (32.3) | 19 (22.4) | 31 (28.2) | .108 |
a
ALT, alanine aminotransferase; AST, aspartate aminotransferase; bpm, beats per minute; CBD, common bile duct; CT, computed tomography; ERCP, endoscopic retrograde cholangiopancreatography; Q1, first quartile; Q3, third quartile; RUQ, right upper quadrant; SBP, systolic blood pressure; Tmax, maximum temperature; US, ultrasonography.
b
Data are presented as No. (percentage) of patients unless indicated otherwise.
c
First 24 hours during admission.
d
During admission.