Table 1.
| Variable | N | Overall (N=110) | Nontransplant patients (n=56) | Transplant patients (n=54) | P value |
|---|---|---|---|---|---|
| Age (y) | 110 | 64.9 (23.9, 86.6) | 69.2 (23.9, 86.6) | 59.5 (26.4, 80.4) | .003 |
| Sex: male | 110 | 70 (63.6) | 31 (55.4) | 39 (72.2) | .077 |
| Alcohol abuse | 110 | 3 (2.7) | 2 (3.6) | 1 (1.9) | 1.00 |
| IV drug use | 110 | 1 (0.9) | 1 (1.8) | 0 (0.0) | 1.00 |
| Diabetes | 110 | 38 (34.5) | 8 (14.3) | 30 (55.6) | <.001 |
| CKD | 110 | <.001 | |||
| Any CKD stage | 21 (19.1) | 8 (14.3) | 13 (24.1) | ||
| ESRD on dialysis | 17 (15.5) | 0 (0.0) | 17 (31.5) | ||
| Coronary artery disease | 110 | 42 (38.2) | 17 (30.4) | 25 (46.3) | .12 |
| COPD | 110 | 18 (16.4) | 10 (17.9) | 8 (14.8) | .80 |
| Liver disease | 110 | 4 (3.6) | 2 (3.6) | 2 (3.7) | 1.00 |
| Malignancy | 110 | 24 (21.8) | 10 (17.9) | 14 (25.9) | .36 |
| Solid tumors | 110 | .12 | |||
| No tumors | 92 (83.6) | 49 (87.5) | 43 (79.6) | ||
| Localized tumor | 12 (10.9) | 3 (5.4) | 9 (16.7) | ||
| Metastatic tumor | 6 (5.5) | 4 (7.1) | 2 (3.7) | ||
| Hematologic malignancy | 110 | 7 (6.4) | 3 (5.4) | 4 (7.4) | .71 |
| Chemotherapy within 6 mo before diagnosis | 110 | 7 (6.4) | 5 (8.9) | 2 (3.7) | .44 |
| Rheumatologic disease treated with immunosuppressive therapy | 110 | 15 (13.6) | 10 (17.9) | 5 (9.3) | .27 |
| Previous trauma/surgery of the infected site | 110 | 9 (8.2) | 6 (10.7) | 3 (5.6) | .49 |
| High corticosteroid dose within 6 mo before diagnosisc | 110 | 23 (20.9) | 7 (12.5) | 16 (29.6) | .035 |
| Dose of methylprednisolone pulse | 21 | 60 (20, 2500) | 40 (20, 60) | 313 (20, 2500) | .012 |
| Low CD4 count before diagnosis | 110 | 15 (13.6) | 3 (5.4) | 12 (22.2) | .012 |
| Lowest CD4 count before diagnosis | 15 | 75 (1, 258) | 176 (31, 188) | 74 (1, 258) | .47 |
| TMP-SMZ prophylaxis at diagnosis | 110 | 17 (15.5) | 2 (3.6) | 15 (27.8) | <.001 |
| Taking corticosteroids | 110 | 72 (65.5) | 22 (39.3) | 50 (92.6) | <.001 |
| Daily corticosteroid dose | 72 | 10.0 (1.0, 80.0) | 20.0 (5.0, 80.0) | 10.0 (1.0, 60.0) | .003 |
| Taking immunosuppressive medicationsd | 110 | 60 (54.5) | 9 (16.1) | 51 (94.4) | <.001 |
a
CKD = chronic kidney disease; ESRD = end-stage renal disease; COPD = chronic obstructive pulmonary disease; IV = intravenous; TMP-SMZ = trimethoprim sulfamethoxazole.
b
Data are presented as median (minimum, maximum) or as No. (percentage). P values comparing nontransplant and transplant patient results from the Wilcoxon rank sum test (continuous variables) or Fisher exact test (categorical variables).
c
High-dose corticosteroids >20 mg of prednisone equivalent daily for >1 mo.
d
Cyclosporine, tacrolimus, azathioprine, mycophenolate mofetil, sirolimus, or other immunosuppressive medications.