Table 4.
| Nocardia sp Antibiogram (invasive disease) | Total isolates | Amikacin | Amox/clavulanate | Ceftriaxone | Cefepime | Ciprofloxacin | Clarithromycin | Doxycycline | Imipenem | Linezolid | Minocycline | Moxifloxacin | TMP-SMZ | Tobramycin |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nocardia brasiliensis | 18 | 100 (16/16) | 100 (14/14) | 6 (1/17) | 0 (0/12) | 0 (0/17) | 6 (1/17 ) | 0 (0/9) | 13 (2/16) | 100 (15/15) | 19 (3/16) | 45 (5/11 ) | 100 (16/16 ) | 88 (15/17 ) |
| Nocardia farcinica | 18 | 100 (14/14) | 100 (14/14) | 6 (1/17) | 8 (1/13) | 71 (12/17) | 5.8 (1/17) | 0 (0/9) | 87.5 (14/16 ) | 100 (11/11 ) | 20 (3/15 ) | 100 (9/9 ) | 100 (14/14 ) | 0 (0/15 ) |
| Nocardia nova | 16 | 94 (15/16) | 0 (0/10) | 47 (7/15 ) | 67 (4/6 ) | 0 (0/15) | 100 (15/15) | 0 (0/6 ) | 94 (14/15) | 100 (11/11) | 7 (1/15) | 0 (0/7) | 100 (15/15) | 13 (2/16) |
| Nocardia asteroides (probably cyriacigeorgica) | 14 | 100 (10/14 ) | 50 (3/6) | 56 (5/9) | 100 (1/14) | 38 (3/8) | 67 (6/9) | 50 (1/2) | 67 (6/9) | 100 (4/4) | 22 (2/9) | 50 (1/2) | 100 (8/8) | 67 (6/9) |
| Nocardia cyriacigeorgica | 15 | 100 (15/15) | 2 (2/13 ) | 60 (9/15) | 15 (2/13) | 0 (0/15) | 0 (0/14 ) | 8 (1/12 ) | 100 (15/15) | 100 (15/15) | 0 (0/15) | 7 (9/14) | 100 (15/15) | 100 (15/15) |
| Nocardia beijingensis | 7 | 100 (7/7) | 0 (0/5) | 100 (7/7) | 33 (1/3 ) | 0 (0/7) | 57 (4/7) | 0 (0/2 ) | 86 (6/7) | 86 (6/7) | 100 (7/7) | 100 (1/1) | 100 (7/7) | 100 (7/7) |
| Nocardia sp | 7 | 80 (4/5 ) | 50 (1/2 ) | 33 (2/6) | 0 (0/2) | 0 (0/5) | 80 (4/5) | 0 (0/2) | 80 (4/5) | 100 (3/3) | 60 (3/5) | 50 (1/2 ) | 100 (6/6) | 60 (3/5) |
| Nocardia pseudobrasiliensis | 5 | 100 (5/5) | 0 (0/5) | 0 (0/5) | 0 (0/5) | 100 (5/5) | 100 (5/5) | 0 (0/5) | 0 (0/5) | 80 (4/5) | 20 (1/5) | 100 (5/5) | 40 (2/5) | 100 (5/5) |
| Nocardia abscessus complexe | 2 | 100 (2/2) | 100 (2/2) | 100 (2/2) | 100 (2/2) | 0 (0/2) | 50 (1/2) | 100 (2/2) | 0 (0/2) | 100 (2/2) | 100 (2/2) | 0 (0/2) | 100 (2/2) | 100 (2/2) |
| Nocardia amikacinitolerans | 2 | 0 (0/2) | 100 (2/2) | 100 (2/2) | 100 (2/2) | 0 (0/2) | 0 (0/2) | 100 (1/1) | 100 (2/2) | 100 (2/2) | 100 (2/2) | 0 (0/2) | 100 (2/2) | 100 (2/2) |
| Nocardia asteroides complexf | 2 | 100 (2/2) | 0 (0/2) | 50 (1/2) | N/A | 0 (0/2) | 100 (2/2) | N/A | 100 (2/2) | 100 (2/2) | 0 (0/2) | 0 (0/2) | 100 (2/2) | 50 (1/2) |
| Nocardia niwae | 2 | 100 (2/2) | 0 (0/2) | 100 (2/2) | 0 (0/2) | 0 (0/2) | 100 (2/2) | 50 (1/2) | 100 (2/2) | 100 (2/2) | 100 (2/2) | 100 (2/2) | 100 (2/2) | 100 (2/2) |
| Nocardia veterana | 2 | 100 (2/2) | 0 (0/2) | 0 (0/2) | 100 (2/2) | 0 (0/2) | 100 (2/2) | 0 (0/2) | 100 (2/2) | 100 (2/2) | 0 (0/2) | 0 (0/2) | 100 (2/2) | 50 (1/2) |
| Nocardia abscessus | 1 | 100 (1/1) | 0 (0/1) | 100 (1/1) | 100 (1/1) | 0 (0/1) | 0 (0/1) | 100 (1/1) | 100 (1/1) | 100 (1/1) | 100 (1/1) | 0 (0/1) | 100 (1/1) | 100 (1/1) |
| Nocardia higoensis/shimofusensis | 1 | 100 (1/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 100 (1/1) | 100 (1/1) | 0 (0/1) | N/A | 100 (1/1) | 100 (1/1) |
| Nocardia kruczakiae | 1 | 100 (1/1) | 0 (0/1) | 0 (0/1) | 100 (1/1) | 0 (0/1) | 100 (1/1) | 0 (0/1) | 100 (1/1) | 100 (1/1) | 100 (1/1) | 0 (0/1) | 100 (1/1) | 0 (0/1) |
| Nocardia otitidiscaviarum | 1 | 100 (1/1) | 0 (0/1) | 0 (0/1) | N/A | 0 (0/1) | 100 (1/1) | N/A | 0 (0/1) | 100 (1/1) | 0 (0/1) | N/A | 100 (1/1) | 0 (0/1) |
| Nocardia transvalensis/wallacei | 1 | 100 (1/1) | 100 (1/1) | 100 (1/1) | 0 (0/1) | 100 (1/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 100 (1/1) | 0 (0/1) | 100 (1/1) | 100 (1/1) | 0 (0/1) |
| Nocardia wallacei | 1 | 0 (0/1) | 100 (1/1) | 100 (1/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 100 (1/1) | 100 (1/1) | 100 (1/1) | 100 (1/1) | 0 (0/1) |
| Nocardia yamanashiensis | 1 | 100 (1/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 0 (0/1) | 100 (1/1) | 0 (0/1) | 0 (0/1) | 100 (1/1) | 0 (0/1) | 0 (0/1) | 100 (1/1) | 0 (0/1) |
a
N/A = not available; TMP-SMZ = trimethoprim-sulfamethoxazole.
b
Data presented are percent susceptible.
c
Only counts invasive disease and includes Clinical and Laboratory Standards Institute-listed agents.
d
Only counts susceptible, not intermediate.
e
Nocardia abscessus complex includes N abscessus, N arthritidis, N asiatica, N beijungensis, and N pneumoniae.
f
Nocardia aseroides complex includes N abscessus, N brevicatena/paucivorans, N nova complex, N transvalensis complex, N farcinica, and N cyriacigeorgica.