Table 2.
Comparison of Renal Outcomes Between Patients Prescribed ACEi/ARB or Sacubitril-Valsartan Using Inverse Probability of Treatment Weighting
| Outcome | Sacubitril-valsartan (n=6424) |
ACEi/ARB (n=24,034) |
Hazard ratio (95% CI) | P value | ||||
|---|---|---|---|---|---|---|---|---|
| No. of events | Person-years | Rate per 100 person-years | No. of events | Person-years | Rate per 100 person-years | |||
| ≥30% decline in eGFR | 256 | 3691.63 | 6.93 | 315 | 3944.64 | 7.98 | 0.87 (0.70-1.07) | .18 |
| Doubling of serum creatinine | 103 | 3755.38 | 2.74 | 112 | 4014.89 | 2.78 | 0.99 (0.74-1.32) | .95 |
| Acute kidney injury | 139 | 4777.48 | 2.91 | 186 | 5161.62 | 3.60 | 0.80 (0.62-1.02) | .08 |
| Kidney failure | 98 | 4817.39 | 2.03 | 129 | 5187.32 | 2.48 | 0.82 (0.61-1.10) | .18 |
ACEi/ARB = angiotensin-converting enzyme inhibitor/angiotensin receptor blocker; eGFR = estimated glomerular filtration rate.