Figure 1.

Apoferritin increased the body weight and improved motor deficits of MPTP-induced mice

(A) Experimental scheme of MPTP model.

(B and C) Apoferritin inhibited MPTP-induced weight loss in mice. ΔWeight means the weight change of mice.

(D and E) Injection of MPTP (intraperitoneal) induced a significant increase of pole-climbing time and turnaround time in pole-climbing test, which was inhibited by apoferritin.

(F and G) In the open-field test, the decrease in the total movement distance in 10 min induced by MPTP was also improved by apoferritin.

^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001, compared with the control; ^#p < 0.05, ^##p < 0.01, compared with the MPTP. Data were expressed as mean ± SEM (n = 5–9 in each group).