Figure 5.

Apoferritin suppressed MPTP-induced ferroptosis in the SN by regulating ferroptosis associated protein

(A) Apoferritin did not restore MPTP-induced decrease in the expression of GPX4.

(B) MPTP and pretreatment with apoferritin did not affect the levels of GSH/GSSG Figures 5C and 5D.

(C) Apoferritin suppressed MPTP-induced up-regulation of ACSL4.

(D) The expression of FSP1 decreased in the SN of MPTP-induced mice, which could be suppressed by apoferritin.

^∗p < 0.05, ^∗∗p < 0.01, compared with the control. ^#p < 0.05, compared with the MPTP. Data were expressed as mean ± SEM (n = 5–8 in each group).