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. 2021 Apr 16;24(5):102446. doi: 10.1016/j.isci.2021.102446

Figure 2.

Figure 2

IL-1β upregulates IL-33 expression by promoting TAK1, ERK, and p38 pathway in mADSC

(A) Western blot of p-ERK, ERK, p-p38, p38, and Tubulin in mADSC stimulated with or without IL-1β for 2 h

(B) Il33 mRNA expression in mADSC stimulated with or without IL-1β, ERK inhibitor, or p38 inhibitor for 6 h

(C) Il33 mRNA expression in mADSC stimulated with or without IL-1β, TAK1 inhibitor for 6 h.

(D) Western blot of IL-33 and GAPDH in mADSC stimulated with or without IL-1β, TAK1 inhibitor, ERK inhibitor, or p38 inhibitor for 24 h.

(E) Western blot of p-ERK, ERK, p-p38, p38, and GAPDH in mADSC stimulated with or without IL-1β, TAK1 inhibitor for 1 h. Data are pooled from three (B and C) independent experiments or are representative of three (A, D, and E) independent experiments. In (A), Student's t test was used. In (B), (C), and (E) one-way ANOVA was used. Bars, mean; error bars, SEM; ∗p < 0.05, ∗∗p < 0.01.