Figure 5.

WT ADSCs increase the frequency and an absolute number of CD4⁺Foxp3⁺ST2⁺ Tregs in the submandibular glands of NOD/ShiLtj mice

(A) Frequency and absolute number of Foxp3⁺ T cells in the submandibular glands of NOD/ShiLtj mice injected with PBS, ADSC from WT or Il33^−/− mice.

(B) Frequency and absolute number of ST2⁺ T cells in CD4⁺Foxp3⁺ T cell in the submandibular glands of NOD/ShiLtj mice injected with PBS, ADSC from WT or Il33^−/− mice.

(C) Frequency and absolute number of Ki67⁺ in CD4⁺Foxp3⁺ T cells in the submandibular glands of NOD/ShiLtj mice injected with PBS, ADSC from WT or Il33^−/− mice.

(D) Absolute number of CD45⁺ cells in the submandibular glands of NOD/ShiLtj mice injected with PBS, ADSC from WT or Il33^−/− mice.

(E) Absolute number of CD45⁺TCRβ⁺CD4⁺ cells per mg of submandibular gland of NOD/ShiLtj mice injected with PBS, ADSC from WT or Il33^−/− mice.

(F) Absolute number of CD45⁺TCRβ⁺CD8⁺ cells in the submandibular glands of NOD/ShiLtj mice injected with PBS, ADSC from WT or Il33^−/− mice.

(G) Absolute number of CD45⁺TCRγδ⁺ cells in the submandibular glands of NOD/ShiLtj mice injected with PBS, ADSC from WT or Il33^−/− mice. Data are pooled from three independent experiments. One-way ANOVA was used. Bars, mean; error bars, SEM; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.