Figure 5.

The gut microbiota established by different dietary nutrient compositions had a large impact on the plasma lipid profile

(A) Schematic overview of the lipidomic study.

(B) PCA analysis of the cecal microbiota compositions in the colonized (Col) mouse groups fed one of the experimental diets each for 2 weeks (10 weeks of age).

(C–E) Heatmap of the class of lipid metabolites. The ratios of the levels in the Col mice to the levels in the GF mice are shown as log-2-fold changes. (C) Fatty acids and neural lipids. (D) Sphingolipids. (E) Phospholipids. The statistical significances of the differences between the GF and Col mice were determined by Student's t test (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001).

(F) Heatmap of Spearman's rank correlation coefficient between individual microbial genera and plasma lipid metabolites. Excludes genera that were present at percentages of less than 1% and rho values of less than |0.7|.