Figure 6.

Neurodegeneration in Aβ42 fly brains

Aβ flies exhibit age-dependent neurodegeneration in the cell body areas of the brains

(A–C) Representative images show paraffin-embedded, H&E-stained brain sections of control (A) and Aβ42 flies (B and C), respectively. Scale bars represent 200 μm (A and B) and 50 μm (C). Vacuolar areas are indicated by arrows, and the cell body area (hemisphere) is surrounded by a green dotted line.

(D) Percentages of vacuolar areas were analyzed. Means ± SEM, n = 24–26 hemispheres, ^∗∗∗p < 0.001 by Student’s t-test. The genotypes of the flies are as follows: (Control) elav-GAL4/Y, (Aβ42): elav-GAL4/Y; UAS-Aβ42/+. Flies were 3 weeks old.