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. 2021 May 8;10:66. doi: 10.1186/s40249-021-00853-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Geographic expansion of MERS a and its relationship with transportation network and land cover b in the Middle East. The first invasion time of each space unit was defined as the time lag between the first confirmed case for each unit and September 20, 2012, the symptom onset date of the first confirmed case in the Middle East Region. The time between adjacent contours was fixed at 200 days, and a wide gap between adjacent contours indicates a faster spatial diffusion of the disease. The inset map in panel a was added to present the early onset situation in the whole Middle East during the first 400 days.