Table 4.

Residues with the most significant interaction energies at the dimer-DNA interface in H2A.B systems in kcal/mol

H2A.B NCP
H2A.B histone			H2B histone
Residue	Location	ΔEtotal (kcal/mol)	Residue	Location	ΔEtotal (kcal/mol)
ARG17	α N helix	−7.7 ± 0.9	SER52	L1 loop	−1.3 ± 0.8
THR18	α N helix	−0.2 ± 0.2	SER53	α2 helix	−2.9 ± 1.2
ARG42	L1 loop	−4.7 ± 1.2	ARG83	L2 loop	−4.4 ± 1.1
LEU43	L1 loop	0.1 ± 0.5	SER84	L2 loop	−3.7 ± 1.6
SER44	L1 loop	−3 ± 0.8	THR85	L2 loop	−6 ± 1.1

Negative values correspond to interactions that stabilize DNA binding.