Figure 7.
The dependence of Ca cycling homeostasis on CaM. (A) Plot of the average NSR load (cnsr) as a function of CaM is given. (B) Plot of the average diastolic Ca concentration as a function of CaM is given. Both the average diastolic Ca and NSR load are computed just before the 31st AP is triggered. The cell is paced at CL = 400 ms. (C) Longitudinal linescan of subcellular Ca at the indicated levels of [CaM] is shown. (D) The total number of sparks divided by CL for the last beat is given, taken at steady state after pacing for 30 beats. Error bars are computed as the standard deviation of 10 independent simulation runs. To see this figure in color, go online.