Table 3. Factors Associated With CVD and Total Mortality for Combinations of Factors Among Participants With Obesity (NHANES-III, n = 2511)a.
| Variable | CVD mortality | Total mortality | ||
|---|---|---|---|---|
| AUROC (95% CI) | Change in AUROC | AUROC (95% CI) | Change in AUROC | |
| Waist circumference | 0.684 (0.681 to 0.688) | NA | 0.633 (0.630 to 0.635) | NA |
| Waist-to-hip ratio | 0.702 (0.697 to 0.706) | NA | 0.640 (0.639 to 0.642) | NA |
| BMI | 0.516 (0.513 to 0.520) | NA | 0.518 (0.516 to 0.519) | NA |
| Systolic BP | 0.775 (0.770 to 0.781) | NA | 0.696 (0.694 to 0.699) | NA |
| QUICKI | 0.553 (0.545 to 0.561) | NA | 0.551 (0.546 to 0.556) | NA |
| Fasting glucose | 0.574 (0.562 to 0.586) | NA | 0.605 (0.601 to 0.610) | NA |
| Hemoglobin A1c | 0.644 (0.638 to 0.651) | NA | 0.608 (0.603 to 0.612) | NA |
| C-reactive protein | 0.553 (0.547 to 0.560) | NA | 0.530 (0.526 to 0.534) | NA |
| γ-Glutamyltransferase | 0.618 (0.603 to 0.632) | NA | 0.565 (0.557 to 0.574) | NA |
| SBP | 0.775 (0.770 to 0.781) | [Reference] | 0.696 (0.694 to 0.699) | [Reference] |
| SBP + WHR | 0.802 (0.797 to 0.806) | 0.026 (−0.009 to 0.062) | 0.720 (0.718 to 0.722) | 0.024 (0.001 to 0.047) |
| SBP + WHR | NA | [Reference] | NA | [Reference] |
| SBP + WHR + WC | 0.804 (0.799 to 0.808) | 0.002 (−0.013 to 0.017) | 0.724 (0.722 to 0.726) | 0.004 (−0.005 to 0.013) |
| SBP + WHR + HbA1c | 0.805 (0.801 to 0.809) | 0.004 (−0.007 to 0.014) | 0.722 (0.720 to 0.724) | 0.002 (−0.003 to 0.007) |
| SBP + WHR + GGT | 0.805 (0.800 to 0.810) | 0.003 (−0.003 to 0.010) | 0.720 (0.719 to 0.722) | 0.000 (−0.001 to 0.002) |
| SBP + WHR + Glucose | 0.802 (0.798 to 0.807) | 0.001 (−0.002 to 0.003) | 0.721 (0.719 to 0.723) | 0.001 (−0.002 to 0.004) |
| SBP + WHR + QUICKI | 0.801 (0.796 to 0.805) | −0.001 (−0.007 to 0.005) | 0.721 (0.719 to 0.723) | 0.001 (−0.003 to 0.004) |
| SBP + WHR + CRP | 0.806 (0.801 to 0.810) | 0.004 (−0.008 to 0.017) | 0.725 (0.723 to 0.726) | 0.004 (−0.005 to 0.013) |
| SBP + WHR + BMI | 0.802 (0.798 to 0.807) | 0.001 (−0.010 to 0.011) | 0.722 (0.720 to 0.724) | 0.002 (−0.005 to 0.008) |
Abbreviations: AUROC, area under the receiver operating characteristic; BMI, body mass index; CRP, C-reactive protein; CVD, cardiovascular disease; GGT, γ-glutamyltransferase; NA, not applicable; NHANES-III, National Health and Nutrition Examination Survey-III; QUICKI, quantitative insulin sensitivity check index; SBP, systolic blood pressure; WC, waist circumference; WHR, waist-to-hip ratio.
a
Exclusion of participants using blood pressure–lowering, glucose-lowering, or lipid-lowering medication.